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Bacterial etiology and antibiotic resistance pattern of pediatric bloodstream infections: A multicenter based study

S Maham1, F Fallah1, Z Gholinejad1

  • 1Pediatric Infections Research Center, Research Institute For Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Annali Di Igiene : Medicina Preventiva E Di Comunita
|June 13, 2018
PubMed

Insights

This study identified common bacteria causing septicemia in children in Iran and their antibiotic resistance patterns. Multiple drug-resistant bacteria are a significant concern, but some local antibiotics remain effective.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Clinical Research

Background:

  • Bloodstream infections (septicemia) pose a significant threat to neonates and children.
  • Understanding causative agents and antibiotic resistance is crucial for effective treatment.

Purpose of the Study:

  • To determine the bacterial etiology of septicemia in pediatric patients.
  • To analyze antibiotic resistance patterns of common bacterial isolates in Tehran, Iran.

Main Methods:

  • Retrospective cross-sectional study over two years (2014-2016).
  • Standard microbiological methods for bacterial isolation and identification from blood cultures.
  • Antimicrobial susceptibility testing using the disk diffusion method.

Main Results:

  • Gram-negative bacteria (55.4%) were predominant, with Pseudomonas spp. being the most common.
  • High prevalence of antibiotic resistance, including methicillin-resistant Staphylococcus aureus (52.6%) and vancomycin-resistant enterococci (68.8%).
  • Overall prevalence of multiple-drug resistant isolates was 83.4%.

Conclusions:

  • Multiple drug-resistant bacteria play a major role in pediatric septicemia.
  • Certain locally available antibiotics show promising efficacy against these resistant isolates.
Abstract

Keywords:
Antibiotic resistanceBloodstream infectionIranNeonatePediatric

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