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Low-dose guar improves diabetic control.

D B Jones, P Slaughter, S Lousley

    Journal of the Royal Society of Medicine
    |July 1, 1985
    PubMed
    Summary
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    Guar granulate supplementation significantly improved glycosylated hemoglobin (HbA1c%) in diabetic patients over two months, with levels returning to baseline after discontinuation. This dietary fiber intervention showed potential for better glycemic control with minimal side effects.

    Area of Science:

    • Endocrinology
    • Nutritional Science
    • Metabolic Disorders

    Background:

    • Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia.
    • Effective glycemic control is crucial for preventing long-term diabetic complications.
    • Dietary interventions, including fiber supplementation, are explored for managing diabetes.

    Purpose of the Study:

    • To investigate the impact of guar granulate on glycemic control and lipid profiles in diabetic outpatients.
    • To assess the efficacy of a low-dose guar supplementation regimen.

    Main Methods:

    • A prospective study involving 20 diabetic outpatients (12 non-insulin-treated, 8 insulin-treated).
    • Participants received 10g of guar granulate daily for two months.
    • Glycosylated hemoglobin (HbA1c%), fasting blood glucose, postprandial glucose, 24-hour urinary glucose, and lipid levels were monitored.

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    Main Results:

    • Mean HbA1c% significantly decreased from 11.1% to 10.1% after two months of guar supplementation (P < 0.0001).
    • HbA1c% levels reverted to baseline after guar discontinuation.
    • No significant changes were observed in fasting blood glucose, postprandial glucose, urinary glucose excretion, or lipid levels.
    • Gastrointestinal side effects were reported in 4 patients; some patients required reduced insulin or sulfonylurea dosages due to hypoglycemic symptoms.

    Conclusions:

    • Low-dose guar granulate supplementation may improve glycemic control in diabetic patients, as indicated by reduced HbA1c%.
    • The intervention appears to have a low incidence of gastrointestinal side effects.
    • Further research may explore optimal dosing and long-term effects of guar in diabetes management.