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[Passage into the human milk and clinical evaluation of sulbactam/cefoperazone]

S Matsuda, T Kashiwagura, H Hirayama

    The Japanese Journal of Antibiotics
    |February 1, 1985
    PubMed

    A combined agent of sulbactam, a beta-lactamase inhibitor, plus cefoperazone (SBT/CPZ: 1/1) was studied on the passage into the maternal milk as well on the clinical application and the results were followings: One or 2 grams of SBT/CPZ was given by one shot intravenous injection to puerperal mothers to determine the passage into the milk up to 6 hours after the administration. A trace of passage was detected for both SBT and CPZ as in the case of other antibiotics. Good clinical efficacy was observed in all 5 patients with female genital organ infections, to whom a daily dose of 2.0 g of SBT/CPZ was administered by drip infusion for 4 to 6 days. No side effects were noticed.

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