Related Experiment Video

Updated: Feb 9, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

4.1K

Maternal Serum and Breast Milk Adiponectin: The Association with Infant Adiposity Development

Marhazlina Mohamad1, See Ling Loy2, Poh Ying Lim3

  • 1School of Nutrition and Dietetics, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu 21300, Malaysia. marhazlina@unisza.edu.my.

International Journal of Environmental Research and Public Health
|June 14, 2018
PubMed

Insights

Maternal adiponectin (a hormone) in serum and breast milk may protect against infant obesity. Higher levels were linked to lower infant weight, BMI, and abdominal circumference in the first year.

Area of Science:

  • Reproductive biology
  • Pediatric endocrinology
  • Nutritional science

Background:

  • Childhood obesity is a growing concern in Malaysia.
  • Maternal metabolic changes during pregnancy influence infant adiposity.
  • Adipokines, like adiponectin and leptin, play a role in metabolic regulation.

Purpose of the Study:

  • To investigate the association between maternal serum and breast milk adipokines (adiponectin and leptin) and infant adiposity development.
  • To understand the role of maternal adipokine profiles in early life obesity prevention.

Main Methods:

  • Prospective cohort study of 155 healthy pregnant mothers in Kelantan, Malaysia (2010-2012).
  • Maternal serum and breast milk samples analyzed for adiponectin and leptin.
  • Infant anthropometry (weight, BMI-for-age Z-scores, abdominal circumference) measured at birth, 2, 6, and 12 months postpartum.
  • Multiple linear regression analysis used to assess associations.

Main Results:

  • Increased maternal serum and breast milk adiponectin levels were significantly associated with decreased infant weight, BMI-for-age Z-scores, and abdominal circumference in the first year (p < 0.05).
  • No significant association was found for leptin levels.
  • Maternal adiponectin levels demonstrated a protective effect against infant adiposity development.

Conclusions:

  • Maternal serum and breast milk adiponectin are associated with reduced infant adiposity in the first year of life.
  • Adiponectin may be a potential biomarker for predicting and preventing childhood obesity.
  • Targeting maternal adipokine levels could be a strategy for early intervention against infant obesity.

Keywords:
adipokinesadiponectinbreast milkinfant adiposityleptinobesitypregnancy

More Related Videos

A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect05:04

A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect

Published on: September 22, 2023

1.1K
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

20.0K

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.5K
Associative Learning01:27

Associative Learning

Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.4K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
312
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.7K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.8K
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
890