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Epilepsy and Seizures: Overview

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Updated: Feb 9, 2026

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

New Tools for Epilepsy Therapy.

Chiara Falcicchia¹, Michele Simonato^1,2, Gianluca Verlengia^1,2

¹Department of Medical Sciences, Section of Pharmacology, and Neuroscience Center, University of Ferrara and National Institute of Neuroscience, Ferrara, Italy.

Frontiers in Cellular Neuroscience

|June 14, 2018

Summary

New cell and gene therapies offer hope for treating refractory epilepsies when drugs fail. These innovative approaches, including cell biodelivery systems, are advancing toward clinical trials for drug-resistant epilepsy patients.

Keywords:

cell therapy delivery devices epilepsy gene therapy herpes-based vector

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Area of Science:

Neuroscience
Biotechnology
Medical Research

Background:

Epilepsy affects millions worldwide, with a significant portion being refractory to standard antiepileptic drugs (AEDs).
The need for novel therapeutic strategies for drug-resistant epilepsy is critical.

Purpose of the Study:

To explore alternative treatments for focal epilepsies beyond conventional antiepileptic drugs (AEDs).
To discuss the potential of cell-based and gene therapy approaches for treating drug-resistant epilepsy.

Main Methods:

Review of direct cell grafting and gene therapy as potential epilepsy treatments.
Discussion of advanced tools like encapsulated cell biodelivery (ECB) devices and novel gene therapy vectors.
Assessment of progress toward clinical translation of these novel therapies.

Main Results:

Cell grafting and gene therapy show promise as alternatives to AEDs for focal epilepsies.
Encapsulated cell biodelivery (ECB) systems and advanced gene therapy vectors are key innovations.
Rapid advancements suggest these therapies may soon be ready for clinical testing.

Conclusions:

Cell and gene therapy represent promising avenues for treating drug-resistant epilepsy.
Technological advancements are accelerating the translation of these therapies to clinical practice.
There is optimism for the future clinical application of cell and/or gene therapy in epilepsy management.