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Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer

Yang Shao1,2, Hui Li2,3, Ran Du2,3

  • 1Cancer Institute, Fudan University Shanghai Cancer Center.

Journal of Cancer
|June 14, 2018
PubMed

Insights

Non-coding RNAs (ncRNAs) are crucial in ovarian cancer (OC) development and chemoresistance. This review highlights ncRNAs as potential therapeutic targets for improving OC treatment outcomes.

Area of Science:

  • Gynecological Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Ovarian cancer (OC) is a lethal gynecological malignancy with poor survival rates, often diagnosed at late stages.
  • Chemoresistance presents a major challenge in OC treatment, leading to poor prognosis and high recurrence rates.
  • Non-coding RNAs (ncRNAs) are emerging as key regulators of gene expression with significant roles in carcinogenesis.

Purpose of the Study:

  • To review current research on the role of ncRNAs in ovarian cancer chemoresistance.
  • To describe the intricate relationships between ncRNAs and chemoresistance in OC.
  • To identify ncRNAs as potential therapeutic targets for overcoming OC chemoresistance.

Main Methods:

  • Comprehensive literature review of studies investigating ncRNAs and ovarian cancer chemoresistance.
  • Analysis of next-generation sequencing (NGS) data to identify regulatory roles of ncRNAs.
  • Synthesis of findings on microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in OC chemoresistance.

Main Results:

  • ncRNAs are significantly correlated with chemoresistance across various cancers, including ovarian cancer.
  • Specific miRNAs and lncRNAs have demonstrated clear associations with chemoresistance mechanisms in OC.
  • ncRNAs influence gene expression, impacting OC development and response to therapy.

Conclusions:

  • ncRNAs are pivotal in the development and progression of ovarian cancer.
  • Understanding ncRNA involvement in chemoresistance offers novel therapeutic strategies for OC.
  • Targeting ncRNAs presents a promising avenue for improving treatment efficacy and patient outcomes in ovarian cancer.
Keywords:
chemoresistancelncRNAsmiRNAsncRNAsovarian cancer

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