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Patterns of Acute Toxicity Associated with New Psychoactive Substances

Simon L Hill1, Paul I Dargan2

  • 1The Medical Toxicology Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. simon.hill@ncl.ac.uk.

Handbook of Experimental Pharmacology
|June 14, 2018
PubMed

Insights

Understanding new psychoactive substances (NPS) toxicity is crucial. This study uses data triangulation to detail acute, non-fatal NPS toxicity patterns, aiding clinical understanding.

Area of Science:

  • Clinical Toxicology
  • Pharmacology
  • Public Health

Background:

  • New psychoactive substances (NPS) pose significant clinical toxicology challenges.
  • Limited data availability and source limitations complicate understanding NPS toxicity.
  • Accurate characterization of acute toxicity is vital for public health and clinical management.

Purpose of the Study:

  • To highlight the importance of understanding clinical patterns of acute toxicity from NPS.
  • To address challenges in data collection and identify available information sources.
  • To present a data triangulation approach for a comprehensive understanding of NPS toxicity.

Main Methods:

  • Utilized multimodal literature searching to identify key NPS and related toxicity data.
  • Employed a data triangulation methodology to integrate diverse, limited data sources.
  • Combined mechanism of action data with clinical features for a holistic view.

Main Results:

  • Descriptive accounts of acute toxicity patterns for significant NPS were compiled.
  • The data triangulation approach successfully synthesized information from various sources.
  • Clinical examples illustrated the application of the methodology in understanding NPS toxicity.

Conclusions:

  • Data triangulation offers a robust method for characterizing NPS acute toxicity.
  • Integrating clinical features and mechanism of action provides a comprehensive understanding.
  • This work serves as a complete reference for NPS acute toxicity patterns.
Keywords:
CathinonesDrug of abuseFentanylsNPSNew psychoactive substancesNovel psychoactive substancesOpioidsOverdoseSCRASynthetic cannabinoid receptor agonistsToxicityToxidrome

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