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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs
1Department of Obstetrics & Gynaecology, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.
Abstract:
In vivo pregnant study protocols covering preconceptional exposure as well as prenatal and postnatal development including the lactation period to screen the toxic effects on specific elements of the highly complicated reproductive cycle are time-consuming and expensive. Morphology-based whole embryo culture is the most common alternative in vitro embryotoxicity method to evaluate the early developmental toxicity of drugs. Here we share our procedures and experience in the whole embryo culture for drug embryotoxicity assessments.
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