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Updated: Feb 9, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
[Synthesis and antitumor activity of phosphonate derivatives containing amino acid]
Abstract:
In search of effective anticancer agents, fifteen new phosphonate derivatives were designed and synthesized. Their structures were clearly established by elemental analysis, IR, (1)H NMR and (13)C NMR, and their antitumor activities were evaluated by MTT assay. Preliminary results in bioactivity tests indicated that some title compounds exhibited better activity. Among the active compounds, compounds 4e, 4n had better inhibition effect on A-549 cells growth with IC(50) values of 8.7 ± 0.8, 8.2 ± 1.0 μmol·L(-1), the IC(50) values of compound 4c was 9.8 ± 0.9 μmol·L(-1) against SGC-7901 cells and compounds 4l, 4n exhibited more potent activities against EC-109 with IC(50) values of 9.5 ± 0.6, 9.4 ± 0.5 μmol·L(-1).
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