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An Oxidative Dearomatization Approach To Prepare the Pentacyclic Core of Ryanodol
Chen Xu1,2, Arthur Han2, Sarah E Reisman2
1Shenzhen Grubbs Institute , Southern University of Science and Technology (SUSTech) , Shenzhen , 518055 , China.
Abstract:
An approach to synthesize the pentacyclic framework of the polyol diterpenoid ryanodol is reported. The ABC tricycle was constructed by a Co-mediated Pauson-Khand reaction, and both radical and anionic cyclization pathways were developed to form the E-ring. In addition, a reaction sequence involving SeO2-mediated enone oxidation and hydroxyl-directed oxy-Michael addition was developed to introduce the A-ring oxidation. The feasibility of forming the bridging D-ring by an oxidative dearomatization was established.
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