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Updated: Feb 9, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia
Bruce G Lindsey1, Sarah C Nuding1, Lauren S Segers1
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida , Tampa, Florida.
Abstract:
Advances in our understanding of brain mechanisms for the hypoxic ventilatory response, coordinated changes in blood pressure, and the long-term consequences of chronic intermittent hypoxia as in sleep apnea, such as hypertension and heart failure, are giving impetus to the search for therapies to "erase" dysfunctional memories distributed in the carotid bodies and central nervous system. We review current network models, open questions, sex differences, and implications for translational research.
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