Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Packaging00:58

DNA Packaging

112.9K
Overview
112.9K
Chromatin Packaging01:32

Chromatin Packaging

19.4K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
19.4K
Chromatin Packaging02:21

Chromatin Packaging

22.3K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
22.3K
Chromatin Packaging02:21

Chromatin Packaging

9.8K
9.8K
Random and Systematic Errors01:20

Random and Systematic Errors

15.2K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.2K
Systematic Sampling Method01:17

Systematic Sampling Method

13.4K
Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncontrolled Hypertension Prevalence, Characteristic Profiles, and Risk of Cardiorenal and Metabolic Outcomes: Insights from the EnligHTN Study.

Advances in therapy·2026
Same author

Transitional initiatives for advancing the phasing out of the use of animals for drug and chemical safety testing: The IHI VICT3R project for reducing the use of animals by implementing virtual control groups.

NAM journal·2026
Same author

Integrating Genetic Variants and Expression Profiles of Pharmacogenes to Investigate Resistance to Antidepressant Treatment.

Medicina (Kaunas, Lithuania)·2026
Same author

The effect of childhood trauma on the severity of depressive symptoms and drug resistance in major depressive disorder - results from the international PROMPT study.

Journal of affective disorders·2026
Same author

Natural language querying of biological databases with large language models.

Drug discovery today·2026
Same author

Integrating human exposome data into next-generation risk assessment: a systematic framework to infer real-life exposure levels and prioritize chemical compounds for testing.

Environment international·2026

Related Experiment Video

Updated: Feb 9, 2026

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

9.7K

comoRbidity: an R package for the systematic analysis of disease comorbidities.

Alba Gutiérrez-Sacristán1,2, Àlex Bravo1,3, Alexia Giannoula1

  • 1Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences (DCEXS), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Bioinformatics (Oxford, England)
|June 14, 2018
PubMed
Summary

This study introduces comoRbidity, an R package for analyzing disease comorbidities. It integrates clinical data and genetic information to uncover disease associations and potential molecular mechanisms.

More Related Videos

Reporter-based Growth Assay for Systematic Analysis of Protein Degradation
07:47

Reporter-based Growth Assay for Systematic Analysis of Protein Degradation

Published on: November 6, 2014

11.1K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.6K

Related Experiment Videos

Last Updated: Feb 9, 2026

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

9.7K
Reporter-based Growth Assay for Systematic Analysis of Protein Degradation
07:47

Reporter-based Growth Assay for Systematic Analysis of Protein Degradation

Published on: November 6, 2014

11.1K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.6K

Area of Science:

  • Computational biology
  • Bioinformatics
  • Genomics

Background:

  • Comorbidities significantly impact patient health outcomes and healthcare costs.
  • Electronic Health Records (EHRs) offer a valuable resource for identifying disease associations.
  • There is a need for advanced analytical tools to detect comorbidities and their genetic underpinnings.

Purpose of the Study:

  • To present comoRbidity, an open-source R package for comprehensive comorbidity analysis.
  • To enable the investigation of disease comorbidities from both clinical and molecular viewpoints.
  • To facilitate the discovery of disease associations and underlying genetic mechanisms.

Main Methods:

  • Leverages user-provided clinical data from EHR databases for clinical comorbidity analysis.
  • Utilizes genotype-phenotype information for molecular comorbidity analysis.
  • Incorporates functions for sex/age stratification, temporal directionality, and shared gene exploration.

Main Results:

  • comoRbidity provides systematic analysis of disease comorbidities.
  • Enables identification of significant clinical disease associations.
  • Supports hypothesis generation for molecular mechanisms through shared gene analysis.

Conclusions:

  • comoRbidity expedites the integrative analysis of disease comorbidities.
  • Offers a unified platform for clinical and molecular comorbidity research.
  • A valuable tool for researchers studying complex disease patterns.