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Updated: Feb 9, 2026
08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
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MARDy: Mycology Antifungal Resistance Database
Anthony Nash1,2, Thomas Sewell2, Rhys A Farrer2,3
1Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Bioinformatics (Oxford, England)
|June 14, 2018
Summary
Antifungal drug resistance is a growing threat. The Mycology Antifungal Resistance Database (MARDy) provides crucial data on resistance mechanisms to aid research and combat this global challenge.
Area of Science:
- Mycology
- Antimicrobial Resistance
- Bioinformatics
Background:
- Rising antifungal drug resistance poses a significant threat to human health, agriculture, and food security.
- Understanding the genetic and molecular mechanisms underlying antifungal resistance is critical for developing effective countermeasures.
- Existing data on antifungal resistance mechanisms are fragmented, necessitating a centralized resource.
Purpose of the Study:
- To establish a comprehensive, curated web-service database for antifungal drug resistance mechanisms.
- To provide a centralized repository for data on amino acid substitutions, tandem repeat sequences, and genome ploidy in fungi.
- To facilitate research into the causes and spread of antifungal resistance.
Main Methods:
- Development of the Mycology Antifungal Resistance Database (MARDy) using a Linux, Apache, MySQL, and PHP platform.
- Integration of a local BLASTn installation for searching curated gene databases.
- Data curation focusing on amino acid substitutions, tandem repeat sequences, and genome ploidy.
Main Results:
- MARDy offers a curated collection of antifungal drug resistance mechanisms.
- The database includes data on genetic variations such as amino acid substitutions and genome ploidy.
- A BLASTn tool is integrated for efficient searching of resistance-related genes.
Conclusions:
- MARDy serves as a valuable resource for researchers studying fungal antifungal resistance.
- The database aids in understanding the complex mechanisms driving antifungal drug resistance.
- Accessible data in MARDy can contribute to strategies for mitigating resistance in clinical and agricultural settings.
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