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Regulation of Skeletal Homeostasis

Mone Zaidi1, Tony Yuen1, Li Sun1

  • 1Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Endocrine Reviews
|June 14, 2018
PubMed

Insights

Recent skeletal biology research reveals new mechanisms controlling bone remodeling and cell communication. This work explores how bone interacts with other organs for therapeutic targeting.

Area of Science:

  • Skeletal Biology
  • Cellular Communication
  • Organ Crosstalk

Background:

  • Advances in skeletal biology stem from identifying disease mutations.
  • Gene-targeting technologies enable phenocopying human diseases in mice.

Purpose of the Study:

  • Discuss newly identified mechanisms controlling bone remodeling.
  • Explore bone cell communication with other lineages.
  • Examine bone-organ crosstalk for therapeutic targeting.

Main Methods:

  • Review of recent research findings.
  • Analysis of gene-targeting technologies.
  • Discussion of cellular and organ interactions.

Main Results:

  • Identification of novel bone remodeling mechanisms.
  • Elucidation of bone cell communication pathways.
  • Understanding of bone's crosstalk with vital organs.

Conclusions:

  • New insights into skeletal biology mechanisms.
  • Potential for novel therapeutic targeting of the skeleton.
  • Importance of inter-organ communication in skeletal health.

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