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Treatment of type 2 diabetes: future approaches
Clifford J Bailey1, Caroline Day1
1Department of Biomedical Sciences, School of Life and Health Sciences, Aston University, Birmingham, UK.
Introduction Or Background:
Type 2 diabetes, which accounts for ~90% of all diabetes, is a heterogeneous and progressive disease with a variety of causative and potentiating factors. The hyperglycaemia of type 2 diabetes is often inadequately controlled, hence the need for a wider selection of glucose-lowering treatments.
Sources Of Data:
Medline, PubMed, Web of Science and Google Scholar.
Areas Of Agreement:
Early, effective and sustained control of blood glucose defers the onset and reduces the severity of microvascular and neuropathic complications of type 2 diabetes and helps to reduce the risk of cardiovascular (CV) complications.
Areas Of Controversy:
Newer glucose-lowering agents require extensive long-term studies to confirm CV safety. The positioning of newer agents within therapeutic algorithms varies.
Growing Points:
In addition to their glucose-lowering efficacy, some new glucose-lowering agents may act independently to reduce CV and renal complications.
Areas Timely For Developing Research:
Studies of potential new glucose-lowering agents offer the opportunity to safely improve glycaemic control with prolonged efficacy and greater opportunity for therapeutic individualisation.
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