Paraneoplastic Demyelinating Neuropathy, a Multifactorial Disease and Approach to Management

We report a 53-year-old male with demyelinating polyneuropathy due to a paraneo- plastic syndrome from lymphoplasmacytic lymphoma. This syndrome is an immune-mediated event via plasma cell dyscrasia. The patient suffered near quadriplegia requiring prolonged ventilation. He was treatedwith systemic therapyforhis malignancy, as well as immunemodulating therapy with a recovery near his baseline. We propose it is important to not only control malignant plasma cell dyscrasia, but also target peripheral antibodies carrying out the attack in order to prevent further damage to the nervous system.