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Vincristine and fine motor function of children with acute lymphoblastic leukemia

Cheryl L Sabarre, Shahrad R Rassekh, Jill G Zwicker

    Canadian Journal of Occupational Therapy. Revue Canadienne D'Ergotherapie
    |June 15, 2018
    PubMed

    Insights

    Vincristine treatment for acute lymphoblastic leukemia may impact children's fine motor skills. Nearly half showed below-average skills, but no direct link to vincristine dose was found, warranting further research.

    Area of Science:

    • Pediatric Oncology
    • Neuro-oncology
    • Childhood Cancer Research

    Background:

    • Vincristine is a standard chemotherapy for acute lymphoblastic leukemia (ALL).
    • Vincristine is known to cause peripheral neuropathy.
    • The impact of vincristine on fine motor function in children with ALL is understudied.

    Purpose of the Study:

    • To describe fine motor skills and function in children with ALL receiving maintenance vincristine.
    • To assess manual dexterity and parent-reported fine motor dysfunction.
    • To explore the relationship between cumulative vincristine exposure and motor function.

    Main Methods:

    • Prospective case series design.
    • Assessed manual dexterity and parent-reported fine motor dysfunction.
    • Included 15 children with ALL on maintenance vincristine.

    Main Results:

    • Nearly half of the children exhibited below-average fine motor skills compared to age norms.
    • 57% of parents reported functional motor problems in their children.
    • No significant association was found between cumulative vincristine exposure and fine motor skills or dexterity.

    Conclusions:

    • Early detection and intervention for fine motor difficulties in children with ALL are recommended.
    • Larger sample studies are needed to confirm findings and explore vincristine's role in fine motor function.
    • This study highlights potential motor deficits in pediatric ALL patients undergoing vincristine therapy.
    Abstract

    Keywords:
    Activities of daily livingMotor skillsMovement Assessment Battery for Children–2OncologieOncologyPediatricsPédiatrieactivités de la vie quotidiennehabiletés motrices

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