[Antioxidant and anti-inflammatory modulation of exercise during aging]
Fernando Alexis Galle1, Diana Martella2, Guilherme Bresciani3
1Facultad de Ciencias de la Educación, Universidad San Sebastián, Puerto Montt, Chile; Universidad Autónoma de Chile, Chile.
Revista Espanola De Geriatria Y Gerontologia
|June 15, 2018
Summary
Regular moderate exercise in older adults combats age-related decline by enhancing antioxidant defenses and reducing inflammation. This physical activity offers neuroprotection and mitigates chronic inflammation, known as inflamm-aging.
Area of Science:
- Gerontology
- Exercise Physiology
- Immunology
Background:
- Aging leads to reduced functional reserve, sedentary lifestyles, and increased risk factors.
- These factors impair antioxidant defenses, elevating inflammatory and oxidative markers, contributing to inflamm-aging.
- Inflamm-aging is implicated in chronic diseases and age-related cognitive decline.
Purpose of the Study:
- To review the antioxidant and anti-inflammatory effects of moderate-intensity physical exercise in the elderly.
- To present evidence for exercise as a non-pharmacological intervention against aging's deleterious effects.
Main Methods:
- Literature review focusing on studies examining physical exercise in the elderly.
- Analysis of evidence on exercise's impact on antioxidant defenses, inflammatory markers, and neuroprotection.
Main Results:
- Moderate physical exercise effectively modulates antioxidant and anti-inflammatory responses in older adults.
- Exercise demonstrates neuroprotective benefits, enhancing cognitive function associated with aging.
- Physical activity increases circulating anti-inflammatory markers and improves antioxidant defense mechanisms.
Conclusions:
- Moderate exercise is a valuable non-pharmacological strategy to counteract age-related functional decline.
- Exercise mitigates inflamm-aging through improved antioxidant capacity and reduced inflammation.
- Physical activity promotes healthier aging by supporting neuroprotection and systemic anti-inflammatory effects.
Keywords:
AgingCognitive impairmentsDeterioro cognitivoEjercicio físicoEnvejecimientoEstrés oxidativoExerciseInflamaciónInflammationOxidative stressMore Related Videos
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