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Pancreatic Cystic Lesions: Pathogenesis and Malignant Potential
Antoinette J Pusateri1, Somashekar G Krishna2
1Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Antoinette.Pusateri@osumc.edu.
Understanding pancreatic cystic lesions (PCLs) is key to fighting pancreatic cancer. This review details the pathogenesis and malignant potential of PCLs, aiding in early detection and prevention strategies.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Pancreatic cancer is a highly lethal malignancy.
- Early detection and understanding of precursor lesions are crucial for improved outcomes.
- Pancreatic cystic lesions (PCLs) represent a spectrum of precursor entities with varying malignant potential.
Purpose of the Study:
- To review the current literature on the pathogenesis and malignant potential of PCLs.
- To consolidate information on epidemiological, radiological, histological, genetic, and molecular characteristics of PCLs.
- To enhance the understanding of PCLs for improved diagnosis, treatment, and prevention of pancreatic cancer.
Main Methods:
- Comprehensive literature review of recent studies on PCLs.
- Synthesis of data on mucinous PCLs (IPMNs, MCNs), solid pseudopapillary tumors, and cystic neuroendocrine tumors.
- Analysis of epidemiological, radiological, histological, genetic, and molecular features.
Main Results:
- PCLs encompass several types with malignant potential, including mucinous PCLs, solid pseudopapillary tumors, and cystic neuroendocrine tumors.
- Each PCL type exhibits distinct epidemiological, radiological, histological, genetic, and molecular profiles.
- Understanding these characteristics is vital for assessing malignant potential.
Conclusions:
- Further research into PCLs is essential for advancing pancreatic cancer prevention and treatment.
- Detailed characterization of PCLs aids in risk stratification and clinical management.
- Improved knowledge of PCL pathogenesis can lead to novel therapeutic strategies.
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