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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Mass Compression from Recurrent Lymphoma Mimicking Lower Extremity Cellulitis.
David G Li1, Katherine M Krajewski2, Arash Mostaghimi1
1Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, USA.
Cureus
|June 15, 2018
Summary
Recurrent diffuse large B-cell lymphoma (DLBCL) can mimic cellulitis, leading to misdiagnosis. This case highlights the importance of considering malignancy in atypical or refractory leg swelling and redness.
Area of Science:
- Oncology
- Dermatology
- Medical Imaging
Background:
- Cellulitis is a common skin infection often misdiagnosed due to nonspecific symptoms.
- Early diagnosis and treatment are crucial for effective management of infections and malignancies.
Observation:
- A 62-year-old man with a history of diffuse large B-cell lymphoma (DLBCL) presented with unilateral lower extremity swelling and erythema.
- Symptoms initially suggested cellulitis but were refractory to antibiotic treatment.
- Imaging revealed extensive retroperitoneal and pelvic lymphadenopathy compressing the external iliac vein.
Findings:
- Biopsies confirmed recurrent metastatic DLBCL.
- The patient's presentation mimicked cellulitis due to venous and lymphatic obstruction from tumor mass effect.
- Atypical cellulitis features in refractory cases warrant investigation for underlying malignancy.
Implications:
- Clinicians should consider malignancy-induced edema in patients with atypical or refractory cellulitis.
- This case underscores the need for advanced imaging in diagnosing complex presentations.
- Recognizing non-infectious causes of leg swelling is vital for timely cancer diagnosis and treatment.
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