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Updated: Feb 9, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
Leptomeningeal Metastases in Hormone Refractory Prostate Cancer
1Surgery, Gold Coast University Hospital.
Abstract:
Leptomeningeal metastases from the prostate are extremely rare, with few cases described in the medical literature (antemortem prevalence of less than 0.03%). Prostatic leptomeningeal metastases harbour a poor prognosis with a median survival after diagnosis of 15.7 weeks. We present the case of an 82-year-old male with a history of hormone-refractory prostate cancer who presented to the emergency department with neurological symptoms.
Insights
Leptomeningeal metastases from prostate cancer are rare but serious, with a poor prognosis. This case study highlights a rare instance of prostate cancer spreading to the brain
Area of Science:
- Oncology
- Neurology
- Pathology
Background:
- Leptomeningeal metastases (LM) from prostate cancer are exceptionally rare, with an antemortem prevalence below 0.03%.
- Prostatic LM is associated with a poor prognosis, with a median survival of approximately 15.7 weeks post-diagnosis.
- Neurological symptoms can be the initial presentation of advanced prostate cancer.
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