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Relationship between Serum Soluble Klotho Protein and Coronary Artery Calcification and Prognosis in Patients on
Shubei Zheng1, Yu Zheng1, Lingwei Jin1
1Dept. of Nephrology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Insights
Serum soluble Klotho protein (sKlotho) levels are linked to coronary artery calcification (CAC) in maintenance hemodialysis (MHD) patients. Lower sKlotho correlates with higher CAC and poorer survival, but isn
Area of Science:
- Nephrology
- Cardiology
- Biochemistry
Background:
- Maintenance hemodialysis (MHD) patients often exhibit accelerated atherosclerosis.
- Serum soluble Klotho protein (sKlotho) is a key regulator of mineral metabolism and vascular health.
- The association between sKlotho levels and coronary artery calcification (CAC) in MHD patients requires further investigation.
Purpose of the Study:
- To investigate the relationship between serum sKlotho levels and CAC in MHD patients.
- To evaluate the prognostic value of sKlotho in MHD patients.
Main Methods:
- 128 MHD patients were enrolled.
- Serum sKlotho levels were measured using ELISA.
- Coronary artery calcification (CAC) was assessed by multi-slice spiral computed tomography (MSCT).
- Patient outcomes were followed for 36 months.
Main Results:
- Patients with low sKlotho levels had significantly higher prevalence of hypertension and diabetes mellitus.
- Low sKlotho levels were associated with higher coronary artery calcification scores (CACs).
- Decreased sKlotho level was an independent risk factor for CAC progression.
- Mortality and survival time were significantly worse in patients with low sKlotho levels.
Conclusions:
- Serum sKlotho levels are inversely correlated with CAC in MHD patients.
- Low sKlotho levels are associated with increased CAC and poorer prognosis.
- While sKlotho is linked to CAC progression, it was not found to be an independent predictor of prognosis in this cohort.
Background:
We aimed to investigate the relationship between serum soluble Klotho protein (sKlotho) level and coronary artery calcification (CAC) as well as prognosis in patients with maintenance hemodialysis (MHD).
Methods:
Overall, 128 adult patients with end-stage renal failure treated with MHD were collected in the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Zhejiang Province, China in 2013. Serum sKlotho was detected by ELISA and coronary artery calcification was measured by multi-slice spiral computed tomography (MSCT). With 36 months' follow-up, death notes such as cause of death and death time were recorded.
Results:
Patients were divided into low sKlotho group and high sKlotho group. Age, blood phosphorus level, hypertension incidence and incidence of diabetes mellitus of the patients in low sKlotho group was significantly higher than that of high sKlotho group (P<0.05). The coronary artery calcification score (CACs) of patients in high sKlotho group was significantly lower than that of low sKlotho group (P<0.001). Logistic regression showed that the decrease of sKlotho level (P<0.001) was an independent risk factor for CAC progression. The mortality of the patients in low sKlotho group was higher than that of high sKlotho group. Kaplan-Meier survival curve had shown that survival time of the patients in low sKlotho group was significantly lower than that of high sKlotho group (P<0.05).
Conclusion:
SKlotho can increase the degree of CAC. Although MHD patients with low sKlotho level had shorter survival time, sKlotho is not an independent risk factor in prediction of prognosis of MHD patients.
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