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RNA-Seq data on prefrontal cortex in valproic acid model of autism and control rats

Zhaoqiang Qian1, Ruoxin Zhang1,2, Jinlong Zhou2

  • 1Key Laboratory of Modern Teaching Technology, Ministry of Education, Xi'an, Shaanxi 710062, China.

Data in Brief
|June 15, 2018
PubMed

Insights

Valproic acid exposure in pregnant rats models autism, altering gene expression in male offsprings' prefrontal cortex. This RNA-sequencing data reveals key transcriptional and splicing changes relevant to autism research.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition.
  • Valproic acid (VPA) exposure during pregnancy is a known risk factor for ASD.
  • Understanding the molecular mechanisms underlying VPA-induced autism models is crucial.

Purpose of the Study:

  • To present transcriptome sequencing data from a valproic acid (VPA) induced rat model of autism.
  • To investigate transcriptional and splicing alterations in the prefrontal cortex of affected male offspring.

Main Methods:

  • A single intraperitoneal injection of sodium valproic acid (600 mg/kg) was administered to female rats at day 12.5 post-conception.
  • Control rats received saline injection.
  • Male offspring were sacrificed at postnatal day 35, and prefrontal cortex RNA was isolated for RNA Sequencing (RNA-Seq).

Main Results:

  • Transcriptome sequencing data provides a comprehensive view of gene expression changes.
  • The data highlights dysregulation in both transcriptional and splicing events within the prefrontal cortex.
  • Specific molecular pathways affected by VPA exposure are identified.

Conclusions:

  • The VPA-induced rat model exhibits significant transcriptional and splicing abnormalities in the prefrontal cortex.
  • These findings contribute to understanding the molecular basis of VPA-associated neurodevelopmental alterations.
  • The presented data serves as a valuable resource for autism research.

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