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Endothelial microparticles and vascular parameters in subjects with and without arterial hypertension and coronary

Roberto Sansone1, Maximilian Baaken1, Patrick Horn1

  • 1Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany.

Data in Brief
|June 15, 2018
PubMed

Insights

Endothelial microparticles (EMPs) indicate endothelial injury and are elevated in hypertension and coronary artery disease (CAD). This study measured EMPs and vascular function in hypertensive and non-hypertensive individuals with and without CAD.

Area of Science:

  • Cardiovascular Research
  • Endothelial Biology
  • Hypertension Studies

Background:

  • Endothelial microparticles (EMPs) are recognized indicators of endothelial dysfunction and injury.
  • Elevated EMP levels are observed in both arterial hypertension and coronary artery disease (CAD), but their specific role remains unclear.
  • Understanding EMPs' involvement is crucial for diagnosing and managing cardiovascular conditions.

Purpose of the Study:

  • To investigate the association between specific endothelial microparticle (EMP) markers and vascular hemodynamic parameters in individuals with and without arterial hypertension and coronary artery disease (CAD).
  • To elucidate the role of EMPs in the pathophysiology of arterial hypertension and CAD.

Main Methods:

  • EMPs were quantified using flow cytometry, identifying markers such as CD31+/41-, CD62e+, and CD144+.
  • Vascular hemodynamic parameters were assessed, including office and central blood pressure, heart rate, aortic augmentation index, pulse wave velocity, flow-mediated dilation, nitroglycerin-mediated dilation, brachial artery diameter, hyperemic wall shear stress, and laser Doppler perfusion.
  • Participants included normotensive individuals and hypertensive patients, with and without a history of CAD.

Main Results:

  • The study measured specific EMPs and a comprehensive set of vascular hemodynamic parameters in different patient groups.
  • Data were collected from normotensive individuals and hypertensive patients, stratified by the presence or absence of CAD.
  • Detailed analysis correlated EMP levels with various measures of vascular function and blood pressure.

Conclusions:

  • The findings provide insights into the relationship between endothelial microparticles and vascular health in the context of hypertension and coronary artery disease.
  • This research contributes to understanding endothelial injury markers in cardiovascular disease.
  • Further research is warranted to explore the clinical implications of these findings for patient management.

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