Association of ABCG₂ polymorphisms with ischemic stroke in a Chinese population

ATP-binding cassette, superfamily G, member 2 (ABCG₂ ) has been shown to play an important role in the development of ischemic stroke in European and African American populations. The aim of the present study is to test the hypothesis that there are associations between ABCG₂ polymorphisms and ischemic stroke risk in a Chinese population. We conducted a case-control study including 967 participants with ischemic stroke and 939 stroke-free controls. The rs2231137C > T and rs2231142G > T were genotyped using a TaqMan real-time polymerase chain reaction assay. We found the rs2231137C > T and rs2231142G > T in ABCG₂ were significantly associated with ischemic stroke (sex-, age-, BMI-, SBP-, DBP-adjusted OR = 1.252; 95% CI, 1.035-1.515; P-value = 0.021 and OR = 1.526; 95% CI, 1.085-2.146; P-value = 0.015, respectively). By haplotype analyses, the haplotype T-G still had a strongly significant association with ischemic stroke (OR = 0.806; 95% CI, 0.692-0.939; P-value = 0.00568). Our findings identified the rs2231137C > T and rs2231142G > T polymorphisms of the ABCG₂ as risk factors for ischemic stroke in a Chinese population.