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Updated: Feb 9, 2026

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Recent progress in the development of fluorescent probes for hydrazine
Khac Hong Nguyen1, Yuanqiang Hao2, Wansong Chen1
1College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan Province, P. R. China.
Summary
This review summarizes recent fluorescent probes for detecting toxic hydrazine (N2H4). It details probe design strategies and sensing mechanisms for improved safety and environmental monitoring.
Area of Science:
- Analytical Chemistry
- Chemical Sensing
- Toxicology
Background:
- Hydrazine (N2H4) is a vital industrial chemical used in dyes, pharmaceuticals, and pesticides.
- Despite its utility, hydrazine poses significant health risks, including severe liver, kidney, and central nervous system damage.
- Developing selective fluorescent probes for hydrazine detection is crucial for safety and environmental monitoring.
Purpose of the Study:
- To systematically review and categorize recently developed fluorescent probes for hydrazine sensing.
- To discuss the design strategies and sensing mechanisms of these probes.
- To provide a comprehensive overview of the current state of fluorescent hydrazine detection.
Main Methods:
- Literature review of recent studies on fluorescent hydrazine probes.
- Classification of probes based on recognition moieties.
- Analysis of sensing mechanisms and probe design strategies.
Main Results:
- Summarized various fluorescent probes developed for hydrazine detection.
- Categorized probes according to their recognition elements.
- Discussed the relationship between probe structure, spectral properties, and sensing performance.
Conclusions:
- Recent advancements have led to diverse fluorescent probes for hydrazine detection.
- Understanding probe design and sensing mechanisms is key to developing more effective tools.
- This review consolidates recent findings, aiding future research in hydrazine sensing.
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