Jove
Visualize
Contact Us

Related Concept Videos

Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

76.5K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
76.5K
The Uncertainty Principle04:08

The Uncertainty Principle

32.7K
Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that there is a fundamental limit to how accurately one can measure both a particle’s position and its momentum simultaneously. The more accurate the measurement of the momentum of a particle is known, the less accurate the position at that time is known and vice versa. This is what is now called the Heisenberg uncertainty principle. He...
32.7K
The Pauli Exclusion Principle03:06

The Pauli Exclusion Principle

59.5K
The arrangement of electrons in the orbitals of an atom is called its electron configuration. We describe an electron configuration with a symbol that contains three pieces of information:
59.5K
Calculating the Equilibrium Constant02:46

Calculating the Equilibrium Constant

38.1K
The equilibrium constant for a reaction is calculated from the equilibrium concentrations (or pressures) of its reactants and products. If these concentrations are known, the calculation simply involves their substitution into the Kc expression.
For example, gaseous nitrogen dioxide forms dinitrogen tetroxide according to this equation:
38.1K
Calculating Standard Free Energy Changes02:49

Calculating Standard Free Energy Changes

25.6K
The free energy change for a reaction that occurs under the standard conditions of 1 bar pressure and at 298 K is called the standard free energy change. Since free energy is a state function, its value depends only on the conditions of the initial and final states of the system. A convenient and common approach to the calculation of free energy changes for physical and chemical reactions is by use of widely available compilations of standard state thermodynamic data. One method involves the...
25.6K
Calculating pH Changes in a Buffer Solution02:45

Calculating pH Changes in a Buffer Solution

58.8K
A buffer can prevent a sudden drop or increase in the pH of a solution after the addition of a strong acid or base up to its buffering capacity; however, such addition of a strong acid or base does result in the slight pH change of the solution. The small pH change can be calculated by determining the resulting change in the concentration of buffer components, i.e., a weak acid and its conjugate base or vice versa. The concentrations obtained using these stoichiometric calculations can be used...
58.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular Ca<sup>2+</sup> elevations and mitochondrial depolarisation.

Biochemical pharmacology·2024
Same author

Possible Brugada Phenocopy induced by a giant mediastinal lipoma, Re: Brugada-like ECG pattern due to giant mediastinal lipoma.

Hippokratia·2014
Same author

Water equivalent path length measurement in proton radiotherapy using time resolved diode dosimetry.

Medical physics·2011
Same author

Test of GEANT3 and GEANT4 nuclear models for 160 MeV protons stopping in CH2.

Medical physics·2003
Same author

Identification and characterization of a novel secreted immunoglobulin binding protein from group A streptococcus.

Infection and immunity·2001
Same author

Identification and molecular analysis of PcsB, a protein required for cell wall separation of group B streptococcus.

Journal of bacteriology·2001
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 9, 2026

Probe Type II Band Alignment in One-Dimensional Van Der Waals Heterostructures Using First-Principles Calculations
13:56

Probe Type II Band Alignment in One-Dimensional Van Der Waals Heterostructures Using First-Principles Calculations

Published on: October 12, 2019

8.4K

Deterministic proton dose calculation from first principles.

B Gottschalk1

  • 1Harvard University Laboratory for Particle Physics and Cosmology, 18 Hammond St., Cambridge, MA 02138, United States of America.

Physics in Medicine and Biology
|June 15, 2018
PubMed
Summary

A new deterministic pencil beam algorithm accurately calculates proton beam dose in heterogeneous terrain, improving upon existing methods by incorporating realistic collimator effects and reducing the need for beam line measurements.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.1K
Minimal Erythema Dose MED Testing
06:24

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

42.9K

Related Experiment Videos

Last Updated: Feb 9, 2026

Probe Type II Band Alignment in One-Dimensional Van Der Waals Heterostructures Using First-Principles Calculations
13:56

Probe Type II Band Alignment in One-Dimensional Van Der Waals Heterostructures Using First-Principles Calculations

Published on: October 12, 2019

8.4K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.1K
Minimal Erythema Dose MED Testing
06:24

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

42.9K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Physics

Background:

  • Proton therapy requires accurate dose calculation in heterogeneous media.
  • Existing pencil beam algorithms often rely on water-equivalent assumptions and external measurements.
  • There is a need for first-principles dose calculation methods that account for material heterogeneities and beamline physics.

Purpose of the Study:

  • To develop a deterministic pencil beam algorithm for accurate dose computation in proton therapy.
  • To implement a method that handles transverse heterogeneities through dynamic splitting of pencil beams.
  • To validate the algorithm against experimental data and compare it with existing methods.

Main Methods:

  • Discretization of terrain into slabs perpendicular to the beam direction.
  • Transport of pencil beams (PBs) using generalized Fermi-Eyges theory with specific material properties.
  • Dynamic splitting of PBs to resolve transverse heterogeneities.
  • Accumulation of dose contributions at specified measuring planes.

Main Results:

  • The algorithm accurately computes dose in the high-dose region, showing good agreement with experimental data.
  • It effectively models collimator scatter and thickness effects, which are often ignored by conventional algorithms.
  • The method demonstrates good agreement with experimental data in studies of collimator scatter under varying conditions.

Conclusions:

  • The developed deterministic pencil beam algorithm provides accurate dose calculations for proton therapy in heterogeneous environments.
  • It eliminates the need for empirical beamline commissioning measurements, simplifying the process.
  • The algorithm is suitable for both passive beam spreading and pencil beam scanning, with potential for faster computation in PBS.