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Assessment of Left Ventricular Diastolic Function in Egyptian Patients With Behçet's Disease
Heba Farouk1, Hania Salah Zayed2, Basma Sakr2
1Department of Cardiovascular Medicine, Cairo University Hospitals, Cairo, Egypt.
Insights
Egyptian patients with Behçet
Area of Science:
- Cardiology
- Rheumatology
- Echocardiography
Background:
- Behçet's disease is a multisystem inflammatory condition.
- Cardiac involvement, specifically diastolic dysfunction, requires thorough investigation.
- Echocardiography is crucial for assessing cardiac function.
Purpose of the Study:
- To evaluate left ventricular diastolic function in Egyptian Behçet's disease patients.
- To utilize combined transmitral and tissue Doppler velocities for accurate assessment.
- To correlate diastolic parameters with disease manifestations.
Main Methods:
- Forty Behçet's disease patients and 32 healthy controls were enrolled.
- Left ventricular diastolic function assessed using combined transmitral and tissue Doppler parameters.
- Echocardiographic parameters compared between patients and controls.
Main Results:
- Left and right ventricular systolic function were normal in both groups.
- No significant differences in most left ventricular diastolic parameters between groups.
- A subset of patients (15%) showed an E/A ratio <1, correlating with older age and longer disease duration.
- Other echocardiographic parameters were comparable.
Conclusions:
- Egyptian Behçet's disease patients exhibit normal left ventricular diastolic function.
- Diastolic function appears unaffected by disease duration or activity.
- Combined Doppler assessment confirms preserved diastolic function.
Objectives:
This study aims to evaluate left ventricular diastolic function in Egyptian patients with Behçet's disease using variable echocardiographic parameters by combining both transmitral and tissue Doppler velocities to overcome the occasional false interpretation of preload dependent transmitral parameters and to detect the correlation between various left ventricular diastolic parameters and different disease manifestations.
Patients And Methods:
Forty patients (35 males, 5 females; mean age 31±8 years; range 19 to 52 years) with Behçet's disease and 32 age- and sex- matched healthy controls (26 males, 6 females; mean age 28±6 years; range 19 to 60 years) were enrolled. Left ventricular diastolic function was assessed using an algorithm that combined transmitral and tissue Doppler derived parameters.
Results:
Mean disease duration of the patients was 7.4±6 years. Left and right ventricular systolic function was normal in both groups. The transmitral E/A was<1 in six patients (15%). There was no difference between patients and controls regarding the other left ventricular diastolic parameters. Compared to patients with an E/A ratio >1, patients with E/A<1 were significantly older and had a longer disease duration (p=0.001 and p<0.001, respectively). All the other echocardiographic parameters in both groups were comparable.
Conclusion:
Egyptian patients with Behçet's disease have normal left ventricular diastolic function regardless of disease duration and activity.