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Related Experiment Video

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Fast Compensatory Functional Network Changes Caused by Reversible Inactivation of Monkey Parietal Cortex.

Puiu F Balan1,2, Annelies Gerits1, Qi Zhu1,2

  • 1Laboratorium voor Neuro- en Psychofysiologie, KU Leuven Medical School, Campus Gasthuisberg, Leuven, Belgium.

Cerebral Cortex (New York, N.Y. : 1991)
|June 15, 2018
PubMed
Summary

Brain recovery involves rapid network changes. Reversible inactivation of the lateral intraparietal area (LIP) in monkeys revealed compensatory increases in activity in connected brain regions like the frontal eye fields (FEF), aiding task performance.

Keywords:
LIPattention networkfMRImuscimolvisual search

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Cognitive Neuroscience

Background:

  • The brain exhibits significant recovery after injury.
  • Mechanisms of large-scale neural adaptation following focal lesions remain poorly understood.
  • Investigating compensatory changes at the systems level is crucial for understanding brain resilience.

Purpose of the Study:

  • To explore behavioral and functional brain changes induced by focal, reversible inactivation.
  • To elucidate compensatory neural adaptations at the systems level during a cognitive task.
  • To identify brain regions involved in rapid network reorganization after targeted inactivation.

Main Methods:

  • Monkeys performed a covert spatial attention task.
  • Focal, reversible inactivation of the lateral intraparietal area (LIP) using muscimol.
  • Whole-brain functional magnetic resonance imaging (fMRI) to record neural activity.

Main Results:

  • LIP inactivation led to decreased task-related fMRI activity in the targeted area.
  • Heterogeneous network changes were observed, with increased task-related fMRI activity in connected areas, notably the frontal eye fields (FEF).
  • Changes in fMRI activity in areas like FEF and V4 correlated with behavioral performance modifications.

Conclusions:

  • Rapid, large-scale network adaptations occur following focal brain inactivation.
  • Compensatory changes in connected brain regions, particularly FEF, play a key role in maintaining task performance.
  • These adaptive changes likely involve excitation-inhibition dynamics within the intact functional network.