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Electrochemical C-H Cyanation of Electron-Rich (Hetero)Arenes
Davit Hayrapetyan1, Raja K Rit1, Markus Kratz2
1Evonik Chair of Organic Chemistry, Ruhr-Universität Bochum, Universitätsstrasse 150, ZEMOS, 44801, Bochum, Germany.
Abstract:
A straightforward method for the electrochemical C-H cyanation of arenes and heteroarenes that proceeds at room temperature in MeOH, with NaCN as the reagent in a simple, open, undivided electrochemical cell is reported. The platinum electrodes are passivated by adsorbed cyanide, which allows conversion of an exceptionally broad range of electron-rich substrates all the way down to dialkyl arenes. The cyanide electrolyte can be replenished with HCN, opening opportunities for salt-free industrial C-H cyanation.
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