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Related Experiment Videos

Herpes simplex esophagitis--a study in autopsy series.

J Matsumoto, A Sumiyoshi

    American Journal of Clinical Pathology
    |July 1, 1985
    PubMed
    Summary

    Herpes esophagitis, often caused by Herpes Simplex Virus type I, is more common than previously thought, affecting 6% of autopsy cases. This condition, frequently linked to malignant diseases, can be overlooked during post-mortem examinations.

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    Area of Science:

    • Pathology
    • Virology
    • Gastroenterology

    Background:

    • Herpes esophagitis is a rare diagnosis in clinical practice.
    • Esophageal involvement by Herpes Simplex Virus (HSV) can lead to significant morbidity.

    Purpose of the Study:

    • To determine the incidence of herpes esophagitis in autopsy cases.
    • To identify underlying diseases associated with herpes esophagitis.
    • To highlight the potential for this condition to be overlooked.

    Main Methods:

    • Retrospective review of autopsy records and preserved viscera.
    • Immunohistochemical detection of Herpes Simplex Virus type I specific antigen.
    • Analysis of 145 cases with detailed examination and 254 cases with record review.

    Main Results:

    • Herpes esophagitis was identified in 6% (9/145) of cases with detailed examination.
    • Herpes Simplex Virus type I was confirmed in all identified cases.
    • Five additional cases (2%) were found through record review alone.
    • Malignant diseases were present in 8 of the 9 detailed cases.

    Conclusions:

    • Herpes esophagitis is likely more prevalent than previously recognized.
    • The condition may be frequently missed during routine autopsies.
    • Awareness is crucial for clinicians due to potential viral dissemination and available antiviral therapies.

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