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Related Experiment Videos

TORCH tests and what they mean.

J L Sever

    American Journal of Obstetrics and Gynecology
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    TORCH tests assess immunity and infections, but accuracy varies. Enzyme immunoassays are preferred for past infections, while IgM ELISAs and virus isolation are used for recent infections, ensuring reliable diagnostic results.

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    Area of Science:

    • Medical Diagnostics
    • Infectious Diseases
    • Clinical Laboratory Science

    Background:

    • TORCH (Toxoplasmosis, Other, Rubella, Cytomegalovirus, Herpes) tests are crucial for diagnosing congenital infections.
    • A wide array of testing methods, kits, and reporting systems are available, leading to variability in accuracy.
    • Accurate diagnostic testing is essential for appropriate patient management and public health.

    Purpose of the Study:

    • To evaluate the accuracy and reliability of various TORCH testing methodologies.
    • To provide recommendations for preferred laboratory methods for documenting immunity and diagnosing recent TORCH infections.
    • To emphasize the importance of laboratory quality control and proficiency testing.

    Main Methods:

    • Review and comparison of different serological assays, including enzyme immunoassays (EIAs) and IgM enzyme-linked immunosorbent assays (ELISAs).

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  • Discussion of alternative methods like virus isolation for specific TORCH agents.
  • Emphasis on laboratory accreditation and participation in proficiency surveys.

    • Main Results:

    • Enzyme immunoassays are generally preferred for documenting past infections or immunity to TORCH pathogens.
    • IgM ELISAs are recommended for detecting recent toxoplasmosis and rubella infections.
    • Virus isolation is the preferred method for diagnosing recent cytomegalovirus and herpes simplex virus infections.

    Conclusions:

    • Not all available TORCH tests are accurate; some should be avoided.
    • Physicians should utilize laboratories with documented accuracy through proficiency testing.
    • Standardized laboratory practices, including specimen retention, are vital for reliable TORCH testing.