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Phthisis Bulbi-a Clinicopathological Perspective.

Koushik Tripathy1, Rohan Chawla1, Shreyas Temkar1

  • 1a Department of Ophthalmology, Dr. Rajendra Prasad Centre for ophthalmic sciences , All India Institute of Medical Sciences , New Delhi , India.

Seminars in Ophthalmology
|June 15, 2018
PubMed
Summary

Phthisis bulbi is an end-stage eye disease causing shrinkage and vision loss. Early treatment of causes like trauma or infection is key to preventing this condition.

Keywords:
Atrophic bulbiend-stage eyehypotonyphthisical eyeterminal eye disease

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Area of Science:

  • Ophthalmology
  • Pathology

Background:

  • Phthisis bulbi represents the end stage of severe ocular disease.
  • Key pathogenic factors include hypotony, disrupted blood-ocular barriers, and inflammation.

Purpose of the Study:

  • To provide a comprehensive review of phthisis bulbi.
  • To cover etiopathogenesis, pathology, clinical features, and management.

Main Methods:

  • Literature review of end-stage eye disease.
  • Analysis of clinical and microscopic features of phthisical globes.

Main Results:

  • Common causes include trauma, surgery, infection, and inflammation.
  • Clinical signs include a shrunken globe, opaque cornea, and retinal detachment.
  • Microscopic findings involve disorganization, inflammation, calcification, and ossification.

Conclusions:

  • Phthisis bulbi results in irreversible vision loss.
  • Management focuses on cosmetic rehabilitation and pain relief.
  • Early intervention targeting the underlying cause is crucial to prevent phthisis.