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Updated: Feb 9, 2026

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Published on: February 9, 2024
Effect of Physical Exercise on Platelet Reactivity in Patients with Dual Antiplatelet Therapy
Stefan Brunner1, Konstantinos Rizas1, Wolfgang Hamm1
1University Hospital of Munich, Cardiology, Munich, Germany.
Abstract:
It is known that physical exercise may increase platelet activity. However, the effect of exercise on platelet reactivity in patients on dual antiplatelet therapy has not been investigated yet. In our study, 21 patients with coronary artery disease on dual antiplatelet therapy and 10 controls were enrolled. We performed an exercise test using a cycle ergometer and determined the adenosine diphosphate-induced platelet reactivity before and immediately after exercise testing. Additionally, we analysed maximal exercise capacity and an electrocardiogram. Further, we assessed chromogranin A and P-selectin levels and platelet counts.
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