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Updated: Feb 9, 2026
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MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
Published on: May 16, 2012
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Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study
Joseph J Fantony1, Lauren E Howard2,3, Ilona Csizmadi4
1Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Biomarkers in Medicine
|June 16, 2018
Summary
Ki67 expression shows limited prognostic value for biochemical recurrence (BCR) after radical prostatectomy (RP). Further multi-institutional research is needed to confirm its predictive role in prostate cancer outcomes.
Area of Science:
- Oncology
- Urology
- Pathology
Background:
- Biochemical recurrence (BCR) is a key indicator of treatment failure after radical prostatectomy (RP) for prostate cancer.
- Identifying reliable prognostic markers is crucial for predicting patient outcomes and guiding treatment decisions.
Purpose of the Study:
- To evaluate the prognostic significance of Ki67 expression in predicting BCR following RP.
- To assess the utility of Ki67 as a biomarker in a multi-institutional 'real-world' setting.
Main Methods:
- Ki67 immunohistochemistry was performed on tissue microarrays from 464 men who underwent RP.
- Cox regression analysis was used to estimate hazard ratios (HR) for Ki67 expression and time to BCR.
Main Results:
- Ki67 expression was associated with more recent surgery year, positive surgical margins, and extracapsular extension.
- The adjusted HR for Ki67 and BCR approached statistical significance at West LA (HR: 1.54; p=0.06) but not at Durham (HR: 1.10; p=0.74).
Conclusions:
- This multi-institutional study provides limited evidence for the prognostic role of Ki67 in predicting BCR after RP.
- The findings suggest that Ki67 may not be a robust independent predictor of recurrence in this cohort.
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