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[Intervention effects of selenium yeast on fine particulate matters-induced lung injury in rats]

Jie Liu1, Xuejiao Zeng1, Yingying Yang1

  • 1Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.

Wei Sheng Yan Jiu = Journal of Hygiene Research
|June 16, 2018
PubMed
Abstract

Insights

Selenium yeast may protect rat lungs from fine particulate matter (PM 2.5) injury. This study found selenium yeast reduced inflammation and oxidative stress markers in rats exposed to PM 2.5.

Area of Science:

  • Environmental Health
  • Toxicology
  • Nutritional Biochemistry

Background:

  • Ambient fine particulate matter (PM 2.5) poses significant risks to respiratory health.
  • PM 2.5 exposure can induce lung inflammation, oxidative stress, and cellular damage.
  • Selenium is an essential trace element with antioxidant properties.

Purpose of the Study:

  • To investigate the protective effects of selenium yeast against PM 2.5-induced rat lung injury.
  • To evaluate the impact of selenium yeast on inflammatory and oxidative stress markers in the lungs.

Main Methods:

  • Fifty-six rats were divided into groups, including saline control, PM 2.5 exposure, and PM 2.5 exposure with varying doses of selenium yeast.
  • PM 2.5 was administered via intra-tracheal instillation, followed by oral gavage of selenium yeast.
  • Bronchoalveolar lavage fluid was analyzed for neutrophils, inflammatory markers, oxidative stress markers, and cell damage indicators. Lung tissue was examined microscopically.

Main Results:

  • PM 2.5 exposure significantly increased neutrophil proportions and lung pathology scores.
  • Selenium yeast treatment dose-dependently decreased inflammatory markers (TNF-α, IL-1β), cell damage markers (LDH, TP, AKP), and lipid peroxidation (MDA).
  • Selenium yeast administration led to a dose-dependent increase in antioxidant enzyme activities (T-SOD, GSH-Px).

Conclusions:

  • Selenium yeast demonstrates a protective effect against acute lung injury induced by PM 2.5 in rats.
  • Selenium yeast may mitigate PM 2.5 toxicity by reducing inflammation and oxidative stress.
  • These findings suggest selenium yeast as a potential therapeutic agent for PM 2.5-related lung damage.
Keywords:
fine particulate matterintervention effectslung injuryselenium yeast

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