Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stress on an Oblique Plane

Stress on an Oblique Plane

Understanding stress on an oblique plane under axial loading is pivotal in material mechanics. This analysis offers insight into a material's durability and strength, which is crucial for civil engineering and structural design. Axial loading refers to force application along the material's central axis, causing compression or elongation and leading to normal stress. Normal stress occurs when a force acts perpendicularly to the material's area, resulting in compressive or tensile...

Contact Angle

Contact Angle

When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...

Chromatin Position Affects Gene Expression

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Position-effect Variegation

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.

Angle of Twist: Problem Solving

Angle of Twist: Problem Solving

An electric motor applies a torque of 700 N·m to an aluminum shaft, triggering a stable rotation. Two pulleys, B and C, are subjected to torques of 300 N·m and 400 N·m, respectively. The modulus of rigidity is provided as 25 GPa. With the knowledge of the length and diameter of each segment, the twist angle between the two pulleys can be computed. First, a section cut is made between pulleys B and C, and the cut cross-section is analyzed using a free-body diagram. Given that the torque...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

AI-augmented thyroid scintigraphy for robust classification of disease.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026

Same author

Cycle-dependent variation of tumor absorbed dose rates in<sup>177</sup>Lu-DOTATATE therapies.

Biomedical physics & engineering express·2026

Same author

Beyond the tumor: recurrence-prone radiomics for prognostication in negative PSMA PET/CT scans of prostate cancer.

Biomedical physics & engineering express·2026

Same author

Kernel-based maximum likelihood reconstruction of attenuation and activity (MLAA) in SPECT imaging for improved attenuation correction and activity quantification: simulation, phantom and patient validation studies.

Physics in medicine and biology·2026

Same author

A clinically anchored radiomics dictionary for explainable TI-RADS-based thyroid nodule classification in ultrasound; dictionary version TU1.0.

European journal of radiology·2026

Same author

Microenvironment at a Distance: Multi-Endocrine-Organ Radiomics to Identify Systemic Signatures in PSMA-Negative Prostate Cancer.

Cancers·2026

Search research articles

Related Experiment Video

Updated: Feb 9, 2026

Fabrication of Ultra-thin Color Films with Highly Absorbing Media Using Oblique Angle Deposition

Fabrication of Ultra-thin Color Films with Highly Absorbing Media Using Oblique Angle Deposition

Published on: August 29, 2017

Measuring PET Spatial Resolution Using a Cylinder Phantom Positioned at an Oblique Angle.

Martin A Lodge¹, Jeffrey P Leal², Arman Rahmim²

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland; and mlodge1@jhmi.edu.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|June 16, 2018

Summary

A novel PET phantom method precisely measures clinical spatial resolution using an oblique cylinder. This technique offers more relevant estimates than standard methods and aids in standardizing PET data acquisition.

Keywords:

PET cylinder phantom quality assurance spatial resolution standardization

More Related Videos

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

Related Experiment Videos

Last Updated: Feb 9, 2026

Fabrication of Ultra-thin Color Films with Highly Absorbing Media Using Oblique Angle Deposition

Fabrication of Ultra-thin Color Films with Highly Absorbing Media Using Oblique Angle Deposition

Published on: August 29, 2017

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

Area of Science:

Medical Imaging
Nuclear Medicine
Physics

Background:

Accurate spatial resolution measurement is crucial for Positron Emission Tomography (PET) clinical protocols.
Established experimental procedures may not always provide the most relevant spatial resolution estimates for clinical use.
Developing improved methods for assessing PET scanner performance is essential for diagnostic accuracy.

Purpose of the Study:

To introduce and validate a novel method for measuring spatial resolution in clinical PET protocols.
To demonstrate that an oblique cylinder phantom can provide finely sampled edge-spread functions for accurate resolution assessment.
To offer a more relevant and versatile alternative to existing methods for PET spatial resolution evaluation.

Main Methods:

Utilized a 20-cm-diameter water-filled cylinder phantom with a uniform 18F solution, positioned at a slight oblique angle to the PET scanner's z-axis.
Combined line profiles from multiple slices to create a composite profile with fine sampling for edge-spread function analysis.
Measured spatial resolution as full width at half maximum (FWHM) in radial and axial directions, validated with reconstruction parameter modulation and comparison to extended phantoms.

Main Results:

The oblique cylinder method accurately reflected controlled adjustments in post-reconstruction filter parameters.
Measured FWHM values showed clear correlation with increasing positron energy for different isotopes (18F, 11C, 13N, 68Ga, 124I).
Recovery coefficients derived from the method closely matched those from physical phantoms across various conditions.

Conclusions:

A versatile and equipment-independent method for measuring clinical PET spatial resolution has been developed.
The proposed technique provides more relevant estimates than traditional methods and supports PET data acquisition standardization.
This method enables informed selection of reconstruction parameters for optimized PET imaging protocols.