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Acute kidney injury and undiagnosed immunoglobulin A nephropathy after dabigatran therapy

Laurie Jansky1, Pallavi Mukkamala1, Deborah Jebakumar2

  • 1Department of Family and Community Medicine, Baylor Scott & White Health and College of Medicine, Texas A&M Health Science Center, Temple, Texas.

Proceedings (Baylor University. Medical Center)
|June 16, 2018
PubMed

Dabigatran, a new oral anticoagulant, is a direct thrombin inhibitor used as an alternative to warfarin to reduce the risk of stroke and systemic embolism with nonvalvular atrial fibrillation. We report a case of a man who resumed dabigatran after 6 weeks of prior therapy and began experiencing hematuria with worsening kidney function. Renal biopsy with immunofluorescence and electron microscopy showed mesangial deposits consistent with immunoglobulin A nephropathy. With discontinuation of dabigatran and addition of methylprednisolone, the gross hematuria cleared and urine output improved.

Keywords:
Acute kidney injurydabigatranhematuriaimmunoglobulin A nephropathy

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