Related Experiment Video
Updated: Feb 9, 2026

A Colorimetric Assay of Citrate Synthase Activity in Drosophila Melanogaster
Published on: January 16, 2020
Citrate usage in the leading causes of blindness: new possibilities for the old metabolite
Marta Michalczuk1, Beata Urban2, Tadeusz Porowski3
1Department of Paediatric Ophthalmology and Strabismus, Medical University of Białystok, ul. Waszyngtona 17, 15-274, Białystok, Poland. martaa.michalczuk@gmail.com.
Introduction:
Citrate is an old metabolite which is best known for the role in the Krebs cycle. Citrate is widely used in many branches of medicine. In ophthalmology citrate is considered as a therapeutic agent and an useful diagnostic tool-biomarker.
Objectives:
To summarize the published literature on citrate usage in the leading causes of blindness and highlight the new possibilities for this old metabolite.
Methods:
We conducted a systematic search of the scientific literature about citrate usage in ophthalmology up to January 2018. The reference lists of identified articles were searched for providing in-depth information.
Results:
This systematic review included 30 articles. The role of citrate in the leading causes of blindness is presented.
Conclusions:
Citrate might help inhibit cataract progression, in case of questions confirm glaucoma diagnosis or improve cornea repair treatment as adjuvant agent (therapy of ulcerating cornea after alkali injury, crosslinking procedure). However, the knowledge about possible citrate usage in ophthalmology is not widely known. Promoting recent scientific knowledge about citrate usage in ophthalmology may not only benefit of medical improvement but may also limit economic costs caused by leading causes of blindness. Further studies on citrate usage in ophthalmology should continuously be the field of scientific interest.
More Related Videos
Related Concept Videos
Blind Procedures
Blinding
Phase-lead and Phase-lag Controllers
Time and frequency -Domain Interpretation of Phase-lead Control
The design of phase-lead control involves the strategic placement of poles and zeros to balance steady-state error and system...
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
Riboswitches
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...

