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Retinoic Acid Receptor-Related Orphan Receptors: Critical Roles in Tumorigenesis

Jinshuo Fan1, Zhilei Lv1, Guanghai Yang2

  • 1Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Immunology
|June 16, 2018
PubMed

Insights

Retinoic acid receptor-related orphan receptors (RORs) are emerging as key players in cancer development and progression. This review highlights RORs as potential therapeutic targets for various cancers, including breast, melanoma, and lung cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Retinoic acid receptor-related orphan receptors (RORs), including RORα, RORβ, and RORγ, regulate gene transcription via ligand-dependent co-regulator interactions.
  • RORs are implicated in diverse physiological processes such as immune system development, circadian rhythms, and metabolic homeostasis.
  • Growing evidence links RORs to various cancer types, positioning them as potential therapeutic targets.

Purpose of the Study:

  • To review the current understanding of RORs' roles in cancer.
  • To summarize research on the regulatory mechanisms of RORs in cancer.
  • To identify potential therapeutic strategies targeting RORs in oncology.

Main Methods:

  • Literature review of studies investigating RORs in cancer.
  • Analysis of research focusing on ROR regulation and function in neoplastic processes.
  • Synthesis of findings related to RORs as therapeutic targets in various malignancies.

Main Results:

  • RORα is a potential target in breast cancer, melanoma, colorectal, and gastric cancers.
  • RORβ, primarily in the CNS, is studied in pharyngeal cancer, uterine leiomyosarcoma, colorectal cancer, and neuroblastoma.
  • RORγ is implicated in lymphoma, melanoma, and lung cancer, with conflicting reports on its expression levels in tumor tissues.

Conclusions:

  • RORs play significant roles in cancer, acting as potential therapeutic targets.
  • Further research into ROR regulatory mechanisms in cancer is warranted.
  • Targeting RORs may offer novel therapeutic avenues for diverse cancer types.
Keywords:
RORαRORβRORγcancerretinoic acid receptor-related orphan receptors

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