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Relationship between 25-hydroxyvitamin D levels and inflammatory factors in children with asthma attack

Shang Wang1, Yao Pan1, Zhenkun Zhang1

  • 1Department of Pediatric Respiratory Medicine, The Affiliated Children's Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China.

Experimental and Therapeutic Medicine
|June 16, 2018
PubMed

Insights

Low vitamin D levels in children with asthma attacks correlate with increased inflammation and reduced lung function. Supplementation may improve outcomes, suggesting 25-hydroxyvitamin D as a key indicator for childhood asthma management.

Area of Science:

  • Pediatrics
  • Immunology
  • Respiratory Medicine

Background:

  • Asthma attacks in children are often associated with heightened inflammatory responses.
  • The role of vitamin D status in pediatric asthma exacerbations requires further elucidation.

Purpose of the Study:

  • To investigate the association between 25-hydroxyvitamin D [25-(OH)D] levels and inflammatory factors in children experiencing asthma attacks.
  • To evaluate the correlation between 25-(OH)D levels, inflammatory markers, and pulmonary function in pediatric asthma.

Main Methods:

  • A case-control study involving 60 children with asthma attacks and 30 healthy controls.
  • Measurement of biochemical indexes, humoral immunity, Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), and pulmonary function.
  • Stratification of asthmatic children into high and low 25-(OH)D groups for comparative analysis.

Main Results:

  • Asthmatic children exhibited significantly higher leukocytes, neutrophils, eosinophils, IL-6, and TNF-α compared to controls.
  • Children with higher 25-(OH)D levels showed lower IL-6 and TNF-α post-treatment and better treatment outcomes.
  • 25-(OH)D positively correlated with pulmonary function, while IL-6 and TNF-α showed negative associations.

Conclusions:

  • Reduced 25-(OH)D levels in asthmatic children are linked to increased inflammation (IL-6, TNF-α) and impaired pulmonary function.
  • 25-(OH)D levels can serve as a valuable indicator for the prevention and management of childhood asthma.
  • Further research into vitamin D supplementation for pediatric asthma is warranted.

Keywords:
25-(OH)Dasthmainflammationpulmonary function

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