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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
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Extraction: Advanced Methods00:56

Extraction: Advanced Methods

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

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Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
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Related Experiment Video

Updated: Feb 9, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
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Recent advances in transfusions in neonates/infants.

Ruchika Goel1, Cassandra D Josephson2

  • 1Division of Transfusion Medicine, Department of Pathology and Division of Pediatric Hematology/Oncology, Department of Pediatrics, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.

F1000Research
|June 16, 2018
PubMed
Summary

Neonatal transfusions for red blood cells (RBCs), platelets, and plasma are vital. Emerging evidence guides these critical practices, aiming for personalized medicine in neonatal intensive care units.

Keywords:
ChildrenInfantsNeonatesPediatricsPlasmaPlateletsPreemiesPremature InfantsRed Blood CellsTransfusion

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Area of Science:

  • Pediatric Transfusion Medicine
  • Neonatal Intensive Care
  • Hematology

Background:

  • Neonates, especially preterm infants, are the most transfused patient group.
  • Historically, a gap existed between blood product use and evidence-based guidelines in neonates.
  • Pediatric transfusion medicine is advancing with new evidence, technologies, and collaborative research.

Purpose of the Study:

  • To summarize current evidence-based practices for blood component therapy in neonates.
  • To provide data on red blood cell (RBC), plasma, and platelet transfusions.
  • To discuss transfusion thresholds, guidelines, and knowledge gaps in neonatal transfusion medicine.

Main Methods:

  • Review of current evidence-based practices for neonatal blood component therapy.
  • Analysis of data on RBC, plasma, and platelet utilization.
  • Discussion of established and evolving transfusion triggers and thresholds.

Main Results:

  • Evidence is accumulating for red blood cell transfusion triggers and thresholds.
  • Ongoing trials are expected to yield high-quality data for platelet and plasma transfusions.
  • Defining specific cutoff values for anemia, thrombocytopenia, and coagulation abnormalities in neonates remains challenging.

Conclusions:

  • Personalized medicine approaches are crucial for neonatal transfusion decisions.
  • A strong evidence base is essential for guiding neonatal transfusion practices.
  • Addressing research knowledge gaps is vital for advancing neonatal transfusion medicine.