Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Decreasing Function

Decreasing Function

A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2 in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...

Decreased Body Temperature

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...

Decreased pulse rate

Decreased pulse rate

Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...

cAMP-dependent Protein Kinase Pathways

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...

Frequency-dependent Selection

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tracing the Untraceables: A Joint Outbreak Investigation With Law Enforcement Using a Geographic Information System.

Health security·2024

Same author

Effect of radius-dependent diffusion behavior of various gold nanoparticles on photothermal therapy.

Discover nano·2024

Same author

Numerical study on the three-dimensional temperature distribution according to laser conditions in photothermal therapy of peri-implantitis.

International journal of implant dentistry·2024

Same author

Factors associated with the timely diagnosis of malaria and the utilization of types of healthcare facilities: a retrospective study in the Republic of Korea.

Osong public health and research perspectives·2024

Same author

Analysis of Optimal Treatment Starting Time for Photothermal Therapy Through Analysis of Diffusion Behavior of Gold Nanoparticles.

International journal of nanomedicine·2024

Same author

Attachment of various-shaped polystyrene microplastics to silica surfaces: Experimental validation of the equivalent Cassini oval extended DLVO model.

Journal of hazardous materials·2024

Search research articles

Related Experiment Video

Updated: Feb 9, 2026

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

Published on: April 21, 2022

Age-dependent decrease of Nurr1 protein expression in the gerbil hippocampus.

Ji Hyeon Ahn¹, Joon Seok Lee², Jun Hwi Cho²

¹Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea.

Biomedical Reports

|June 16, 2018

Summary

Nuclear receptor related-1 protein (Nurr1) levels decline with age in gerbil hippocampi. This decrease in Nurr1 expression may contribute to age-related cognitive decline.

Keywords:

aging cognitive function gerbil hippocampus nuclear receptor related-1 protein

More Related Videos

Mongolian Gerbils as an Animal Model of Wound Healing

Mongolian Gerbils as an Animal Model of Wound Healing

Published on: January 6, 2023

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Related Experiment Videos

Last Updated: Feb 9, 2026

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

Published on: April 21, 2022

Mongolian Gerbils as an Animal Model of Wound Healing

Mongolian Gerbils as an Animal Model of Wound Healing

Published on: January 6, 2023

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Area of Science:

Neuroscience
Aging Research
Molecular Biology

Background:

Nuclear receptor related-1 protein (Nurr1) is crucial for cognitive functions.
Understanding Nurr1's role in aging is vital for cognitive health.

Purpose of the Study:

To investigate the age-dependent changes in Nurr1 protein expression in the gerbil hippocampus.
To correlate Nurr1 levels with normal aging and cognitive function.

Main Methods:

Western blot analysis to quantify Nurr1 protein levels.
Immunohistochemistry to visualize Nurr1 distribution in hippocampal neurons.
Comparison across three age groups: young (PM 3), adult (PM 12), and aged (PM 24) gerbils.

Main Results:

Nurr1 protein levels significantly decreased with age in the gerbil hippocampus.
Immunoreactivity for Nurr1 was highest in young gerbils, reduced in adults, and lowest in aged gerbils.
Strongest Nurr1 signals were observed in hippocampal pyramidal neurons and granule cells.

Conclusions:

Nurr1 expression gradually and markedly decreases during normal aging in gerbils.
Reduced Nurr1 in the hippocampus is associated with the aging process.
This decline may contribute to age-associated deficits in hippocampus-dependent cognitive function.