Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lectin-binding sites in Paget's disease.

K Tamaki, H Hino, K Ohara

    The British Journal of Dermatology
    |July 1, 1985
    PubMed
    Summary

    Neoplastic cells in Paget's disease exhibit distinct lectin-binding sites. These sites more closely resemble apocrine gland cells than keratinocytes or mammary cells, aiding in understanding disease origins.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Incidence and risk factors for perineal hernia after robotic abdominoperineal resection: a single-center, retrospective cohort study.

    Techniques in coloproctology·2024
    Same author

    Efficacy of laparoscopic surgery for loop colostomy: a propensity-score-matched analysis.

    Techniques in coloproctology·2023
    Same author

    Which is more important in the management of splenic flexure colon cancer: strict central lymph node dissection or adequate bowel resection margin?

    Techniques in coloproctology·2020
    Same author

    Modern precipitation of hydrogenetic ferromanganese minerals during on-site 15-year exposure tests.

    Scientific reports·2020
    Same author

    Robotic-assisted multivisceral resection for rectal cancer: short-term outcomes at a single center.

    Techniques in coloproctology·2017
    Same author

    Electrophysiological effects of desflurane in children with Wolff-Parkinson-White syndrome: a randomized crossover study.

    Acta anaesthesiologica Scandinavica·2017

    Area of Science:

    • Dermatopathology
    • Glycobiology
    • Oncology

    Background:

    • Paget's disease involves neoplastic cells in the epidermis.
    • Understanding the cellular origin and differentiation of these cells is crucial.

    Purpose of the Study:

    • To investigate the lectin-binding sites on neoplastic cells in Paget's disease.
    • To compare these sites with those on normal epidermal and glandular cells.

    Main Methods:

    • Utilized fluorescein isothiocyanate (FITC)-conjugated peanut agglutinin (PNA) and wheat germ agglutinin (WGA).
    • Examined neoplastic cells from mammary and extramammary Paget's disease.
    • Compared staining patterns with keratinocytes and cells from eccrine, apocrine, and mammary glands.

    Main Results:

    • Neoplastic cells in both mammary and extramammary Paget's disease showed cytoplasmic staining with PNA and WGA.
    • Mammary Paget's disease had fewer stained cells compared to extramammary Paget's disease.
    • Apocrine gland cells displayed cytoplasmic staining, unlike the cell-surface staining on keratinocytes, eccrine, or mammary gland cells.

    Conclusions:

    • Lectin-binding sites on Paget's disease cells resemble those of apocrine gland cells.
    • This suggests a potential apocrine origin for extramammary Paget's disease.
    • Findings aid in differentiating Paget's disease origins and understanding its biology.

    Related Experiment Videos