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Updated: Feb 8, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
Variation in prostate cancer treatment and spending among Medicare shared savings program accountable care
Parth K Modi1,2, Samuel R Kaufman2, Tudor Borza1,2
1Division of Oncology, Department of Urology, University of Michigan, Ann Arbor, Michigan.
Background:
Accountable care organizations (ACOs) have been shown to reduce prostate cancer treatment among men unlikely to benefit because of competing risks (ie, potential overtreatment). This study assessed whether the level of engagement in ACOs by urologists affected rates of treatment, overtreatment, and spending.
Methods:
A 20% sample of national Medicare data was used to identify men diagnosed with prostate cancer between 2012 and 2014. The extent of urologist engagement in an ACO, as measured by the proportion of patients in an ACO managed by an ACO-participating urologist, served as the exposure. The use of treatment, potential overtreatment (ie, treatment in men with a ≥75% risk of 10-year noncancer mortality), and average payments in the year after diagnosis for each ACO were modeled.
Results:
Among 2822 men with newly diagnosed prostate cancer, the median rates of treatment and potential overtreatment by an ACO were 71.3% (range, 23.6%-79.5%) and 53.6% (range, 12.4%-76.9%), respectively. Average Medicare payments among ACOs in the year after diagnosis ranged from $16,523.52 to $34,766.33. Stronger urologist-ACO engagement was not associated with treatment (odds ratio, 0.87; 95% confidence interval, 0.6-1.2; P = .4) or spending (9.7% decrease in spending; P = .08). However, urologist engagement was associated with a lower likelihood of potential overtreatment (odds ratio, 0.29; 95% confidence interval, 0.1-0.86; P = .03).
Conclusions:
ACOs vary widely in treatment, potential overtreatment, and spending for prostate cancer. ACOs with stronger urologist engagement are less likely to treat men with a high risk of noncancer mortality, and this suggests that organizations that better engage specialists may be able to improve the value of specialty care. Cancer 2018. © 2018 American Cancer Society.
Insights
Accountable Care Organizations (ACOs) show varied prostate cancer treatment rates. Stronger urologist engagement in ACOs reduces overtreatment in men with competing health risks, improving care value.
Area of Science:
- Urology
- Health Services Research
- Oncology
Background:
- Accountable Care Organizations (ACOs) aim to reduce unnecessary medical treatments.
- Prostate cancer treatment can be overtreatment for men with competing health risks.
- This study investigates urologist engagement within ACOs and its impact on prostate cancer care.
Purpose of the Study:
- To assess the association between urologist engagement in ACOs and prostate cancer treatment rates.
- To determine the effect of urologist engagement on potential overtreatment in prostate cancer care.
- To evaluate the relationship between urologist engagement and healthcare spending for prostate cancer.
Main Methods:
- Analysis of a 20% national Medicare data sample from 2012-2014.
- Identification of men diagnosed with prostate cancer.
- Modeling of treatment, overtreatment, and spending based on urologist-ACO engagement levels.
Main Results:
- No significant association found between urologist-ACO engagement and overall treatment rates or spending.
- Higher urologist engagement in ACOs was linked to a reduced likelihood of overtreatment (OR, 0.29; P=.03).
- Significant variation observed in treatment, overtreatment, and spending across ACOs.
Conclusions:
- ACOs exhibit wide variability in prostate cancer treatment and spending.
- Increased urologist engagement within ACOs correlates with decreased overtreatment for high-risk patients.
- Engaging specialists more effectively in ACOs may enhance the value of specialty care.
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