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Men present with thicker melanoma lesions and higher mitotic rates compared to women. These gender differences in melanoma progression may indicate underlying biological factors influencing prognosis.

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Area of Science:

  • Dermatology
  • Oncology
  • Medical Research

Background:

  • Previous studies indicate gender disparities in melanoma.
  • However, comprehensive research on this phenomenon remains limited.

Purpose of the Study:

  • To investigate gender-associated differences in melanoma characteristics.
  • To analyze the relationship between gender and prognostic factors such as Breslow depth and mitotic rate.

Main Methods:

  • Retrospective chart review of 1,156 adult melanoma patients (2006-2016).
  • Data extraction included Breslow depth, mitotic rate, ulceration, and location.
  • Statistical analysis employed Cochran-Armitage trend tests and cumulative logistic regression.

Main Results:

  • Males showed a higher likelihood of presenting with thicker melanoma lesions (Breslow depth) in univariate analysis (p=0.005).
  • After adjusting for confounders, males remained marginally more likely to have thicker lesions (cumulative OR: 1.261, p=0.060).
  • Males also exhibited a trend towards higher mitotic rates (cumulative OR: 1.244, p=0.074) after comprehensive adjustments.

Conclusions:

  • Gender-specific differences in melanoma progression, particularly in mitotic rates, were observed.
  • These findings suggest potential biological factors contributing to the observed prognosis advantage in females.