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Microcephaly and arbovirus

Luis Del Carpio-Orantes1, María del Carmen González-Clemente

  • 1Instituto Mexicano del Seguro Social, Hospital General de Zona 71, Departamento de Medicina Interna. Veracruz, Veracruz, México neurona23@hotmail.com

Revista Medica Del Instituto Mexicano Del Seguro Social
|June 16, 2018
PubMed
Summary

This study examines microcephaly incidence linked to arboviruses like dengue, chikungunya, and Zika. While dengue shows no association, chikungunya and Zika infections are linked to increased microcephaly cases due to neurotropism.

Keywords:
MicrocephalyChikungunya VirusZika VirusArbovirus Infections

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Area of Science:

  • Neuroscience
  • Virology
  • Epidemiology

Background:

  • Arboviruses are a growing public health concern, with potential neurological implications.
  • Microcephaly, a serious birth defect, has been investigated for links to various infectious agents.
  • Understanding the relationship between arboviruses and microcephaly is crucial for public health strategies.

Purpose of the Study:

  • To investigate the association between different arboviruses and the incidence of microcephaly.
  • To compare the microcephaly rates across dengue, chikungunya, and Zika virus infections.

Main Methods:

  • Review of existing literature and case series on arbovirus infections and microcephaly.
  • Analysis of incidence data from specific cohorts, such as the CHIMERE study for chikungunya.
  • Evaluation of arbovirus neurotropism as a potential mechanism for microcephaly.

Main Results:

  • No cases of microcephaly were reported in association with dengue virus infection.
  • Chikungunya virus infection showed an incidence of microcephaly cases, notably in the CHIMERE cohort.
  • Zika virus infection exhibited the highest incidence of microcephaly, consistent with extensive prior research.

Conclusions:

  • Arboviruses exhibit varying degrees of association with microcephaly.
  • The neurotropic nature of certain arboviruses, including Zika and chikungunya, likely contributes to microcephaly development.
  • Further research into arbovirus neurotropism is warranted to understand and prevent microcephaly.