The importance of presepsin value in detection of gastrointestinal anastomotic leak: a pilot study

Area of Science:

• Surgical oncology
• Gastroenterology
• Biomarker research

Background:

• Anastomotic leakage is a significant complication following gastrointestinal surgery, increasing morbidity and mortality.
• Current monitoring relies on leukocyte count (WBC), C-reactive protein (CRP), and neutrophil-lymphocyte ratio (NLR).
• There is a need for more sensitive and specific markers for early anastomotic integrity assessment.

Purpose of the Study:

• To investigate the utility of presepsin as a biomarker for monitoring anastomotic integrity after gastrointestinal anastomosis.
• To evaluate the diagnostic performance of presepsin in detecting anastomotic leakage.

Main Methods:

• A prospective study involving 100 patients undergoing major abdominal surgery with gastrointestinal anastomosis.
• Blood samples were collected pre-operatively and on postoperative days 1, 3, and 5 to measure WBC, CRP, NLR, and presepsin levels.
• Patients were monitored for the development of anastomotic complications.

Main Results:

• Presepsin levels, along with WBC, CRP, and NLR, showed statistically significant increases in patients who developed anastomotic complications.
• Presepsin demonstrated a high specificity of 98.63% in identifying anastomotic leakage.
• The study suggests presepsin's potential as an early indicator of anastomotic integrity.

Conclusions:

• Presepsin can serve as a valuable supplemental marker for assessing anastomotic integrity.
• Combining presepsin with CRP and NLR may enhance the early diagnosis of anastomotic leakage.
• Further research can explore the integration of presepsin into routine postoperative monitoring protocols.