Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endorphin patterns within the headache spectrum disorders.

G Nappi, F Facchinetti, E Martignoni

    Cephalalgia : an International Journal of Headache
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    p53 status is neither a predictive nor a prognostic variable in patients with advanced ovarian cancer treated with a paclitaxel-based regimen.

    Anticancer research·2001
    Same author

    Serum allopregnanolone in women with postpartum "blues".

    Obstetrics and gynecology·2001
    Same author

    The use of a starting dose of recombinant follicle stimulating hormone for controlled ovarian hyperstimulation: a randomized pilot study.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
    Same author

    Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
    Same author

    Ovarian follicular fluid contains immunoreactive estriol: lack of correlation with estradiol concentrations.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
    Same author

    Dose-response efficacy of a new estradiol transdermal matrix patch for 7-day application: a randomized, double-blind, placebo-controlled study. Italian Menopause Research Group.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
    Same journal

    Rimegepant for migraine prevention in clinical practice: A multicenter study including patients with prior anti-CGRP monoclonal antibody failure (GEMA project).

    Cephalalgia : an international journal of headache·2026
    Same journal

    Cerebrovascular risk with calcitonin gene-related peptide monoclonal antibodies versus onabotulinumtoxinA in patients with migraine: A real-world pharmacoepidemiologic study in the National Institutes of Health All of Us Research Program.

    Cephalalgia : an international journal of headache·2026
    Same journal

    Burning mouth syndrome and oral dysaesthetic/perceptual symptoms: Toward clinically actionable boundaries.

    Cephalalgia : an international journal of headache·2026
    Same journal

    Effectiveness and clinical predictors of rimegepant for acute vertigo in vestibular migraine: A real-world cohort study.

    Cephalalgia : an international journal of headache·2026
    Same journal

    Efficacy of digital therapeutic sinCephalea for personalised nutrition versus control for migraine prevention: A 12-week open-label randomised clinical trial.

    Cephalalgia : an international journal of headache·2026
    Same journal

    SafeTy and effectiveness of Atogepant accoRding to the IHS outcome categories: A multicentric, prospective observational study in real life (the 24-week STAR study).

    Cephalalgia : an international journal of headache·2026
    See all related articles

    Primary headaches are linked to opioid system disturbances, showing reduced endorphin release and impaired adaptability in sufferers. This may explain heightened susceptibility to environmental triggers.

    Area of Science:

    • Neuroendocrinology
    • Neuroscience
    • Pain Research

    Background:

    • Opioid peptides, particularly proopiomelanocortin (POMC)-related peptides, are crucial for nervous system adaptability, stress response, and pain perception.
    • Primary headaches involve complex neuroendocrine, autonomic, and affective factors beyond mere pain.

    Purpose of the Study:

    • To investigate the role of opioid system dysfunction in primary headaches.
    • To evaluate resting plasma and cerebrospinal fluid (CSF) peptide levels and their dynamic changes in response to stimuli in headache sufferers.

    Main Methods:

    • Basal and dynamic studies measuring plasma and CSF peptide levels.
    • Assessment of peptide release from the anterior pituitary in response to physical, endocrine, and pharmacological stimuli.

    Related Experiment Videos

    Main Results:

    • Data support the hypothesis that primary headaches are associated with opioid system disturbances.
    • Headache sufferers exhibit reduced release of endogenous opioids from the anterior pituitary in response to various stimuli.
    • This impaired endorphin responsiveness suggests a weaker adaptive capacity in individuals with primary headaches.

    Conclusions:

    • Primary headaches are sustained by a disturbed opioid system, characterized by reduced endorphin responsiveness.
    • This opioid system impairment may contribute to increased susceptibility to environmental stimuli in headache sufferers.
    • Neuroendocrine techniques can aid in identifying distinct subpopulations of headache patients.