Related Experiment Video

Updated: Feb 8, 2026

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
04:08

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

1.1K

Abnormal lymphocyte response after pediatric thermal injury is associated with adverse outcomes

Rajan K Thakkar1, Zachary Diltz2, Joseph D Drews2

  • 1The Ohio State University College of Medicine, Columbus, Ohio; Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio; Department of Pediatric Surgery, Burn Center, Nationwide Children's Hospital, Columbus, Ohio; Center for Pediatric Trauma Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

The Journal of Surgical Research
|June 17, 2018
PubMed

Insights

An abnormal lymphocyte percentage in pediatric burn patients 72 hours post-injury indicates a higher risk of infection and longer hospital stays. This lab value can predict adverse outcomes in pediatric burn care.

Area of Science:

  • Pediatric Burn Care
  • Infectious Complications
  • Laboratory Diagnostics

Background:

  • Burns are a major cause of childhood morbidity, with infections being the most frequent complication.
  • The predictive value of laboratory findings for infections in pediatric burn patients remains unclear.
  • Severe burns trigger a significant inflammatory response.

Purpose of the Study:

  • To investigate the utility of laboratory values in predicting infections in pediatric burn patients.
  • To determine if white blood cell count, neutrophil, or lymphocyte percentages can predict adverse outcomes.
  • To analyze the association between laboratory values and infection risk post-burn.

Main Methods:

  • Retrospective analysis of a pediatric burn database (patients ≤18 years, ≥10% total body surface area burns).
  • Extracted demographic, clinical, laboratory, and outcome data.
  • Classified white blood cell count, neutrophil, and lymphocyte percentages as abnormal or normal at ≥72 hours post-burn.

Main Results:

  • Abnormal lymphocyte percentage at ≥72 hours post-burn was linked to significantly higher infection rates (67.9% vs. 32.3%, P=0.003).
  • This abnormality also correlated with increased length of stay, ICU stay, and ventilator days.
  • Abnormal lymphocyte percentage independently predicted infection (OR 7.2).

Conclusions:

  • An abnormal lymphocyte percentage at or after 72 hours post-burn is associated with adverse outcomes.
  • This finding highlights the increased infectious risk in pediatric burn patients with abnormal lymphocyte counts.
  • Lymphocyte percentage may serve as a valuable predictive marker in pediatric burn management.
Abstract

Keywords:
BurnInfectionLymphocytePediatric

More Related Videos

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

915
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

1.4K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.9K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.4K
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
815
Thermal expansion and Thermal stress: Problem Solving01:27

Thermal expansion and Thermal stress: Problem Solving

San Francisco's Golden Gate Bridge is exposed to temperatures ranging from -15 °C to 40 °C. At its coldest, the main span of the bridge is 1275 m long. Assuming that the bridge is made entirely of steel, what is the change in its length between these temperatures?
To solve the problem, first, identify the known and unknown quantities. The initial length (L) of the bridge is 1275 m, the coefficient of linear expansion (α) for steel is 12 x 10-6/°C, and the change in temperature (ΔT) is 55...
2.2K
Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
845